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A case report suggests that early use of oral tecovirimat may be an effective treatment for patients with monkeypox and severe proctitis. The report is published in Annals of Internal Medicine.

Monkeypox illness includes systemic symptoms and skin eruptions, and more recent cases have involved proctitis with perianal lesions, some with severe anorectal pain. Researchers from George Washington University School of Medicine and Health Sciences describe monkeypox and its treatment in two patients with monkeypox and severe proctitis in the District of Columbia, which has the highest rate of infection per capita in the United States.

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